Fig. 3
From: Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Characterization of genomic regions harboring aVMPs and associations of gene expression in cis. a Enrichment (odds ratio, y-axis) of aVMPs in chromatin state segments (x-axis) in blood. b Overlap between chromatin state segmentation data in blood and in human embryonic stem cells (hESCs). Numbers represent the number of aVMPs that overlap between segments. c Frequency of aVMPs (y-axis) in 100-kb windows across the genome (blue bars) and their association with gene expression in cis in red. d Frequency of age-related variably methylated regions (aVMRs; x-axis) on each of the autosomal chromosomes (y-axis). e Increased variability (y-axis, top panel) of the protocadherin cluster (bottom panel). Abbreviations: TssA Active transcription start site, TssAFlnk flanking active transcription start site, TxFlnk transcription at gene 5′ and 3′, Tx strong transcription, TxWk weak transcription, EnhG genic enhancers, Enh enhancers, ZNF/Rpts ZNF genes plus repeats, Het heterochromatin, TssBiv bivalent/poised transcription start site, BivFlnk flanking bivalent transcription start site/enhancer, EnhBiv bivalent enhancer, ReprPC repressed polycomb, ReprPCWk weak repressed polycomb, Quies quiescent/low