From: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum
 | Loci with detectable 5hmC in brain (%) | Top 1,000 loci with tissue-specific differences | ||
---|---|---|---|---|
Sites with detectable 5hmC (%) | Enrichment (95Â % CI) | P value | ||
All probes (N = 79,263) | 1,000 | - | - | |
 CpG island feature | ||||
  Island | 7,837 (9.9 %) | 317 (31.7 %) | 4.23 (3.68–4.85) | 6.37E-79 |
  Shore | 22,593 (28.5 %) | 209 (20.9 %) | 0.66 (0.57–0.77) | 6.20E-08 |
  Shelf | 11,674 (14.7 %) | 92 (9.2 %) | 0.59 (0.47–0.73) | 2.64E-07 |
  Outside | 36,342 (45.8 %) | 381 (38.1 %) | 0.73 (0.64–0.83) | 9.82E-07 |
  Unannotated | 817 (1.0 %) | 1 (0.1 %) | 0.10 (0.00–0.54) | 7.00E-04 |
 Gene feature | ||||
  Intergenic | 9,604 (12.1 %) | 132 (13.2 %) | 1.10 (0.91–1.33) | 0.306 |
  Distal promoter | 3,703 (4.7 %) | 25 (2.5 %) | 0.52 (0.34–0.78) | 6.30E-04 |
  Proximal promoter | 16,979 (21.4 %) | 121 (12.1 %) | 0.50 (0.41–0.61) | 3.32E-14 |
  Gene body | 46,238 (58.3 %) | 690 (69.0 %) | 1.59 (1.39–1.82) | 5.15E-12 |
  Downstream | 1,922 (2.4 %) | 31 (3.1 %) | 1.29 (0.87–1.85) | 0.178 |
  Unannotated | 817 (1.0 %) | 1 (0.1 %) | 0.10 (0.00–0.54) | 7.00E-04 |
 Transcription factor binding site | 25,482 (32.1 %) | 125 (12.5 %) | 0.30 (0.25–0.36) | 1.30E-46 |
 Dnase 1 hypersensitivity site | 8,155 (10.3 %) | 280 (28.0 %) | 3.39 (2.94–3.91) | 3.51E-54 |
Alternative transcription events (N = 30,659) | 404 | - | - | |
  A3SS | 798 (2.6 %) | 14 (3.5 %) | 1.34 (0.72–2.29) | 0.270 |
  A5SS | 827 (2.7 %) | 17 (4.2 %) | 1.58 (0.91–2.59) | 0.087 |
  AFE | 9,159 (29.9 %) | 92 (22.8 %) | 0.69 (0.54–0.88) | 1.77E-03 |
  ALE | 3,017 (9.8 %) | 40 (9.9 %) | 1.01 (0.71–1.40) | 0.933 |
  CE | 16,604 (54.2 %) | 202 (50.0 %) | 0.85 (0.69–1.04) | 0.097 |
  CNE | 3,755 (12.2 %) | 69 (17.1 %) | 1.48 (1.12–1.92) | 4.70E-03 |
  EI | 50 (0.2 %) | 1 (0.2 %) | 1.52 (0.04–8.91) | 0.487 |
  II | 6,003 (19.6 %) | 59 (14.6 %) | 0.70 (0.52–0.93) | 0.011 |
  IR | 3,529 (11.5 %) | 54 (13.4 %) | 1.19 (0.87–1.59) | 0.240 |
  MXE | 3,814 (12.4 %) | 39 (9.7 %) | 0.75 (0.53–1.05) | 0.095 |