Fig. 4From: Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signalingGlucocorticoid receptor activation regulates the expression of genes with transcription start sites (TSS) near epigenetic clock CpGs. Gene TSS near epigenetic clock CpGs were identified based on the annotation from [43]. The volcano plot shows DEX-induced fold change in gene expression plotted against their corrected P values (q values). The dotted red line represents the corrected level of statistical significance (q = 5 × 10−2) after FDR correction for multiple comparisons. Among the 216 unique array probes, 167 probes, corresponding to 139 unique genes, showed significant changes in gene expression following DEX. Fifty-eight per cent of these probes (n = 97) showed upregulation and 42 % (n = 70) showed downregulation. The mean (SD, range) distance of each regulated gene TSS to the corresponding epigenetic clock CpGs was ±419.3 bp (336.65 bp, range 1 to 1,423 bp). Marked in red are the probes showing fold changes in gene expression >1.1. Further details are provided in Additional file 2: Table S2Back to article page