Fig. 3

HiC method comparison. Interaction correlations between datasets created with different restriction enzymes for multiple normalization schemes across different binning resolutions. Two datasets are shown, mouse and human. Each mouse dataset was produced using a six-base restriction enzyme. The human datasets were mixed, one produced with a six-base cutter and the other with a four-base cutter. a Data were normalized using several approaches and compared for correlation between two mouse HiC datasets. Interactions were broken down into 10 groups of non-overlapping cis interaction ranges for four resolution levels. b Correlations for 10 different non-overlapping cis interaction ranges at each resolution for each analysis approach. c Overall mouse dataset correlations for each resolution for intra-chromosomal (cis) and inter-chromosomal (trans) interactions. d Overall human dataset correlations for each resolution for intra-chromosomal (cis) and inter-chromosomal (trans) interactions