Table 1 Enrichment of gene ontology (GO) terms among HS-induced and HS-repressed genes and that of GO terms among HS-enriched and HS-depleted SUMO2/3 peaks in K562 cells

Gene group

GO term

Genes (n)

P value

B-H FDR

HS-induced

Response to unfolded protein

21

1.7E-14

4.2E-11

Protein folding

23

2.3E-08

1.1E-05

Programmed cell death

41

4.6E-06

1.2E-03

Apoptosis

39

1.8E-05

4.4E-03

Response to heat

10

4.5E-05

9.9E-03

HS-repressed

Gene expression

225

1.3E-17

3.2E-14

Metabolic process

442

1.7E-16

2.8E-13

Biosynthetic process

251

1.9E-16

1.4E-13

Transcription

155

8.7E-11

1.6E-08

Translation

35

5.4E-06

5.1E-04

Translational elongation

16

4.0E-05

3.6E-03

ncRNA metabolic process

24

2.6E-04

2.1E-02

SUMO2/3 peak group

GO term

Peaks (n)

P value

Bonferroni P value

HS-enriched

Translation

183

1.1E-38

1.0E-34

mRNA metabolic process

278

6.7E-36

5.9E-32

RNA processing

273

3.5E-31

3.1E-27

Viral reproduction

175

1.2E-29

1.1E-25

Translational elongation

80

2.6E-29

2.3E-25

Viral transcription

63

1.5E-27

1.3E-23

Translational termination

64

8.7E-27

7.6E-23

ncRNA metabolic process

132

1.3E-23

1.1E-19

Protein complex disassembly

70

1.3E-22

1.1E-18

RNA splicing

136

3.3E-14

2.9E-10

HS-depleted

Regulation of lipid kinase activity

27

2.9E-06

2.1E-02