Table 1 ADAMTS genes: their chromosomal positions, major tissue expression locations, expression-inducing factors, substrates, and associations with pathologies

ADAMTS1

Ovary, bronchial epithelial cells, fetal lung, placenta, smooth muscle, uterus, adrenal cortex, adipocyte, ciliary ganglion, prostate, olfactory bulb, breast stromal fibroblasts and myoepithelial cells

Progesterone, Brg1, IL-1, S100A8, S100A9, TNFα

Aggrecan, versican, syndecan 4, TFPI-2, semaphorin 3C, nidogen-1, −2, desmocollin-3, dystroglycan, mac-2, gelatin (denatured collagen type I), amphiregulin, TGF-α, heparin-binding EGF

Cancer (both pro- and anti-tumorigenic/metastatic), anti-angiogenic

ADAMTS2

Adipocyte, skeletal muscle, superior cervical ganglion, uterus, placenta, heart, liver, lung, tongue, smooth muscle, breast stromal fibroblasts

Glucocorticoids (in monocytes), IL-6

Fibrillar procollagens types I-III and V

Ehlers-Danlos syndrome type VIIc, dermatosparaxis (in sheep and cattle)

ADAMTS3

CD105+ endothelial cells, CD34+ cells, pineal gland, cartilage, bone, skeletal muscle, tendon, breast myoepithelial cells

Fibrillar procollagen type II, biglycan

ADAMTS4

Ovary, spinal cord, adrenal cortex, ciliary ganglion, trigeminal ganglion, brain, retina, pancreas (islets), fetal lung, breast myoepithelial cells

IL-1 + oncostatin M, TNFα, S100A8, S100A9, leptin, IL-6

Aggrecan, versican, reelin, biglycan, brevican, matrilin-3, α2-macroglobulin, COMP

Arthritis

(HDAC inhibitors, pentosan polysulfate)

ADAMTS5

Adipocyte, uterus, breast myoepithelial cells

IL-1, TNFα, S100A8, S100A9, leptin, IL-6

Aggrecan, versican, reelin, biglycan, matrilin-4, brevican, α2-macroglobulin

Arthritis, cancer (anti-tumorigenic, anti-angiogenic)

(HDAC inhibitors)

ADAMTS6

Superior cervical ganglion, trigeminal ganglion, appendix, heart, breast myoepithelial cells

TNFα,

-

ADAMTS7

Trigeminal ganglion, adrenal cortex, liver, heart, skeletal muscle, intervertebral disc, breast stromal fibroblasts

PTHrP

COMP

Coronary artery disease (smooth muscle cell migration)

(miR-29a/b)

ADAMTS8

Skeletal muscle, heart, liver, superior cervical ganglion, adrenal cortex, breast stromal fibroblasts and luminal epithelial cells

Aggrecan

ADAMTS9

Dorsal root ganglion, breast myoepithelial cells

TNFα, IL1 + oncostatin M, leptin

Aggrecan, versican

Cancer (anti-angiogenic)

(HDAC inhibitors)

ADAMTS10

CD8+ T-cells, brain, uterus, breast stromal fibroblasts

Fibrillin-1

Weill-Marchesani syndrome

ADAMTS12

Liver, bone marrow, atrioventricular node, intervertebral disc, breast stromal fibroblasts and myoepithelial cells

COMP

Cancer (pro- and anti-tumorigenic)

ADAMTS13

Liver, CD71+ early erythroid cells, lung, thyroid, breast myoepithelial cells

(IL-1)

vWF

Thrombotic thrombocytopenic purpura

ADAMTS14

Thalamus, bone marrow, fetal thyroid, adipocyte, cerebellum, bone, skin, fibroblasts, breast myoepithelial and luminal epithelial cells

Fibrillar procollagen type I (pNα1 and pNα2 chains)

ADAMTS15

Colon, brain, heart, uterus, musculoskeletal system, breast myoepithelial cells

Aggrecan, versican

Cancer (anti-tumorigenic/metastatic, anti-angiogenic)

ADAMTS16

Breast myoepithelial cells

Follicle stimulating hormone; forskolin (cAMP);

-

Hypertension

Transcription factors: Wilm’s tumor-1; Egr-1, Sp1

ADAMTS17

Breast myoepithelial cells

-

Weill-Marchesani-like syndrome

ADAMTS18

Ciliary ganglion, heart, skin, brain, breast myoepithelial cells

-

ADAMTS19

Dorsal root ganglion, breast myoepithelial cells

-

ADAMTS20

Brain, appendix, heart, liver, skeletal muscle, pituitary, trigeminal ganglion, breast myoepithelial cells

Versican