Figure 4

Sample result groups that have RHOC as a common downstream target. Oncoprints are shown at the right of each group and unaltered samples are omitted. Gene color intensities are proportional to gene alteration ratios. In the signaling network, dashed green edges represent transcriptional relations and solid blue edges represent post-translational relations. Genes in the result groups are shown inside a compound node, whose label shows the alteration coverage of samples in the group. This is also equal to the visible portion of samples on the oncoprints. Figure prepared using ChiBE [43,44]. (a) Uterine corpus endometrial carcinoma (CNA dominated 56 samples, 49 altered). (b) Lung adenocarcinoma (218 samples, 160 altered). (c) Breast invasive carcinoma (923 samples, 210 altered). (d) Glioblastoma multiforme (112 samples, 98 altered). (e) Uterine corpus endometrial carcinoma (mutation dominated 155 samples, 110 altered).