Figure 3

Simulation study with five trees (A-E). (First column) Sankey plots of the trees used for simulations. For each node, the width of the in-edge is proportional to the clone frequency. The colors denote different layers of the tree (tree depths). Plots were produced with the R package riverplot. (Second column) Performance of clustering methods for the simulation studies with four different noise levels. Performance measures are based on 10,000 MCMC samples (the box plots in the second column). The MPEAR-summarized predictions (marked as BitPhylogeny) outperform the baseline competitors in all data sets with noise. (Third column) Comparison in terms of the summary statistics maximum tree depth and number of clones. For hierarchical clustering and k-centroids, the trees are constructed as minimum spanning trees from estimated clonal methyltypes.