Figure 1From: Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicityPassaging of virus in vivo . In order to give a reproducible model of infection EBOV was passaged five times in guinea pigs in a forced evolution model. There were 10 animals per group, where four animals were used for harvesting spleens for virus preparation and the remaining six animals used to measure clinical parameters.Back to article page