© BioMed Central Ltd 2001
Published: 15 February 2001
Study of the mosquito genome is driven by the need for improved strategies to control the transmission of malaria and other mosquito-borne diseases. In the February 13 Proceedings of the National Academy of Science, Tu describes the use of a novel computer program, FINDMITE, to search systematically for DNA transposable elements in the genome of the African malaria mosquito Anopheles gambiae (Proc Natl Acad Sci USA 2001, 98:1699-1704). The program identified eight novel families of miniature inverted repeat transposable elements (MITEs) that range from 40-1,340 copies per genome (constituting up to 0.8% of the genome). The A. gambiaeMITEs are found in AT-rich regions and appear to be clustered together. The identification of transposable elements may help attempts to create genetically modified mosquitoes to control malaria.
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- Proceedings of the National Academy of Science, [http://www.pnas.org]
- FINDMITE, [http://www.biochem.vt.edu/aedes]
- BBMI Anopheles gambiae genome page, [http://bioweb.Pasteur.fr/BBMI]
- LTR-retrotransposons and MITEs: important players in the evolution of plant genomes.