Open Access

Cycling surprises

  • William Wells
Genome Biology20012:spotlight-20010104-03

DOI: 10.1186/gb-spotlight-20010104-03

Published: 04 January 2001

Array analysis of dividing cells has been tackled for yeast, but in the January Nature Genetics Cho et al. present the first large-scale analysis in human cells (Nat Genet 2001, 27:48-54). They identify731 of 40,000 human genes and expressed sequence tags (ESTs) as being cell cycle regulated in primary fibroblasts, and use a functional classification system to identify coordinate regulation of pathways. Notable surprises include upregulation of motility-related genes in G2 (perhaps to prepare daughter cells for migration away from each other), and of extracellular matrix-associated genes in M (possibly to enhance the re-establishment of cell-cell contact and communication after mitosis).

References

  1. Expression monitoring by hybridization to high-density oligonucleotide arrays.
  2. A genome-wide transcriptional analysis of the mitotic cell cycle.
  3. Nature Genetics, [http://www.nature.com/ng/]
  4. Supplementary data to Nat Genet 2000, 27:48-54, [http://www.salk.edu/LABS/chipdata/]

Copyright

© BioMed Central Ltd 2001

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