Hopping along DNA
© BioMed Central Ltd 2000
Published: 13 July 2000
Oxidative damage yields isolated electrons and their corresponding 'holes' that can migrate along DNA. In the 6 July Nature Lewis et al. determine rate constants of ~5x107 s-1 and 5x106 s-1, respectively, for forward and return hole transport from a single guanine base to a double guanine base across a single adenine (Nature 2000, 406:51-53). These rates mean that electrons do not linger long enough to participate in strand-cleavage reactions. But the electrons move too slowly to avoid charge recombination, so DNA cannot act as a useful molecular wire.
- Distance-dependent electron transfer in DNA hairpins.
- Nature, [http://www.nature.com/nature/]