Lymphocytes in lampreys?
© BioMed Central Ltd 2000
Published: 22 June 2000
The adaptive immune system seems to have burst onto the evolutionary scene in a mere 50 million years, starting ~500 million years ago. Finding intermediate stages has proven difficult. In the June 20 Proceedings of the National Academy of Sciences Shintani et al. find that the lamprey, a jawless vertebrate reported to lack an adaptive immune system, expresses a member of the Spi family of lymphoid transcription factors (Proc. Natl. Acad. Sci. USA 2000, 97:7417-7422). Expression is limited to the ovary (inexplicably) and cells in the gut epithelium that morphologically resemble lymphocytes.
- 'Big Bang' emergence of the combinatorial immune system.
- Proceedings of the National Academy of Sciences, [http://www.pnas.org/]