Open Access

Eat the dead

  • William Wells
Genome Biology20001:spotlight-20000508-03

DOI: 10.1186/gb-spotlight-20000508-03

Published: 08 May 2000

Apoptosis eliminates the asymmetry of plasma membrane phospholipids and exposes phosphatidylserine on the outside of cells. Fadok et al. report in the May 4 Nature that they have found a phagocyte protein that recognizes the phosphatidylserine (Nature 2000, 405:85-90). Addition of the receptor to lymphocytes allows the cells to engulf apoptotic cells. Engagement of the receptor on macrophages induces the production of anti-inflammatory TGF-b consistent with the absence of inflammation during apoptosis.

References

  1. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.
  2. Nature magazine's homepage, [http://www.nature.com/nature/]

Copyright

© BioMed Central Ltd 2000

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