Table 2 Putative novel drivers in ovarian cancer
From: Integrated analysis of recurrent properties of cancer genes to identify novel drivers
Ovarian carcinoma sample | Gene | Ovarian cell lines with increased proliferation | Pathway/Biological process | Reference |
|---|---|---|---|---|
TCGA-04-1525 | SETDB1 | NA | PI3K/RAS | [95] |
| Â | SIPA1L1 | NA | Cytoskeleton organisation | [96] |
TCGA-09-2051 | SPTLC1 | 1 | MYC | [97] |
TCGA-10-0927 | GTF3 | 10 | RB | [98] |
| Â | SQRDL | 1 | Amino acid metabolism | [99] |
TCGA-13-0717 | GRIT | NA | JNK/MAPK | [100] |
TCGA-13-0755 | ANXA2 | 2 | Vesicle transport | [101] |
| Â | FBLN1 | 1 | Cell adhesion | [97] |
| Â | FEN1 | 4 | DNA repair | [102] |
| Â | GSS | 3 | Glutathione metabolism | [103] |
| Â | KDM5B | 14 | RB | [104] |
| Â | MBNL1 | 3 | Splicing regulation | [105] |
| Â | PKP4 | NA | WNT | [106] |
| Â | U2SURP | NA | WNT | [97] |
| Â | WDR61 | NA | Chromatin regulation | [107] |
TCGA-13-1408 | F11R | 0 | Cell adhesion | [108] |
| Â | PELI1 | NA | PI3K/RAS | [109] |
| Â | PTPRG | 23 | WNT | [110] |
| Â | TAF12 | 18 | Transcriptional activation | [111] |
| Â | TIAM1 | 25 | JNK/MAPK | [112] |
TCGA-13-1506 | BTBD2 | NA | NF-kB (transcription) | [113] |
TCGA-13-1510 | RIOK3 | 7 | Unknown | NA |
TCGA-23-1024 | FAM59A | NA | JNK/MAPK | [114] |
| Â | PBX2 | 22 | Transcriptional activation | [115] |
TCGA-24-1431 | ANKZF1 | NA | Unknown | NA |
| Â | ATP1B1 | 0 | Ion transport | [116] |
TCGA-24-1544 | CCDC93 | 10 | Unknown | NA |
| Â | HDAC6 | 1 | Chromatin regulation | [117] |
TCGA-24-1546 | SUGP1 | 7 | Splicing regulation | [99] |
| Â | VAV1 | 14 | JNK/MAPK | [118] |
TCGA-24-1567 | HTATSF1 | 5 | Splicing regulation | [119] |
| Â | INADL | NA | Cell-cell interactions | [120] |
| Â | KAL1 | 0 | Cell adhesion | [121] |
| Â | RAGEF2 | 25 | JNK/MAPK | [122] |
TCGA-25-1623 | PSD3 | NA | Transcriptional activation | [123] |
TCGA-25-1627 | KAT2B | 9 | WNT | [124] |
| Â | PIK3R4 | 1 | PI3K/RAS | [125] |
| Â | TTF2 | 25 | Transcriptional repression | [126] |
TCGA-25-1630 | APEX1 | 9 | DNA repair | [127] |
| Â | ATG3 | NA | Autophagy | [128] |
| Â | CAT | 2 | PI3K/RAS | [129] |
| Â | DCAF6 | NA | Transcriptional activation | [130] |
TCGA-25-1633 | SASH3 | 0 | Antigen receptor signalling | [131] |
TCGA-25-1634 | GSN | 5 | TP53 | [132] |
| Â | MCM4 | 15 | G1/S transition | [133] |
| Â | RBL2 | 25 | RB | [134] |
TCGA-25-2391 | RASA1 | 5 | PI3K/RAS | [135] |
TCGA-25-2393 | ANO1 | 0 | Ion transport | [131] |
| Â | FUT1 | 1 | Antigen synthesis | [136] |
| Â | MCM4 | 15 | G1/S transition | [137] |
| Â | PRKCQ | 22 | PI3K/RAS | [138] |
| Â | RB1CC1 | 8 | RB | [121] |
| Â | ZC3H14 | NA | Translation | [139] |
TCGA-36-1570 | PSD3 | NA | Transcriptional activation | [140] |
TCGA-36-1574 | NRCAM | NA | Cell adhesion | [141] |
| Â | NSMAF | NA | NF-kB (transcription) | [142] |
| Â | PASK | 24 | Translation | [143] |
TCGA-36-1577 | PRKD1 | 1 | Transcriptional activation | [144] |