Study | Design | Sample | Tissue | Method | Significant loci | Remark |
---|---|---|---|---|---|---|
Einstein et al. [16] | Population based | 5 IUGR and 5 AGA | CD34+ hematopoietic stem cells (cord blood) | HELP | 56 loci (P < 0.00001) | |
Banister et al. [37] | Population based | 89 IUGR and 117 AGA | Placenta | HM27 | 22 loci (number predetermined) | |
Fryer et al. [34] | Population based | 12 newborns | Cord blood | HM27 | 304 loci (P < 0.05) | Samples were selected to give a range in LINE1 methylation values |
Adkins et al. [36] | Population based | 201 newborns | Cord blood | HM27 | 10 loci (P < 0.001) | |
Turan et al. [35] | Population based | 48 newborns | Cord blood and placenta | HM27 | 23 loci | Regularized regression model fit was used (R2 > 0.80) |
Gordon et al. [38] | Twin design | 18 MZ and 10 DZa | CBMCs, placenta and UVECs | HM27 | 7 loci in DZ CBMCs 1 loci in MZ UVECs (FDR <0.1) | Twins not selected for birth weight discordancy |