Figure 7
From: Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas
Binarized methylation status in sarcoma cell lines. (a) Binarized methylation status of the selected 35 CpG sites from the primary sarcoma collection in 14 sarcoma cell lines representing different sarcoma subtypes. Cluster-specific CpG sites are bordered in blue for the respective cell lines from which they were originally established. (b) Similarity of the sarcoma cell lines with the seven clusters of primary sarcomas. Both MLS cell lines (MLS402 and MLS1765) and both MPNST cell lines (STS26T and T265) show a significantly higher DNA methylation pattern similarity to their respective primary sarcoma subtypes than any of the other cell lines (P = 0.02 for MLS and MPNST cell lines). The five SS cell lines show a significantly higher methylation pattern similarity to primary SS samples (P = 0.001) than the remaining cell lines. DDLS, dedifferentiated liposarcoma; FS, fibrosarcoma; LS, liposarcoma; MLS, myxoid liposarcoma; MPNST, malignant peripheral nerve sheath tumor; SS, synovial sarcoma; WDLS, well-differentiated liposarcoma.