A. | B. | |||||
---|---|---|---|---|---|---|
Tumor model | Strain | Promoter | Transgene | Reference | Primarily found in murine class(es): | Intramodel variation |
Brg1 +/- | Mixed | Â | Brg1 heterozygous | [7] | Squamous-likeEx (4/12); Erbb2-likeEx (3/12); 3 others | Heterogeneous |
Normal mammary-lactating | FVB | Â | Normal lactating mammary tissue | Â | Normal-likeEx (2/2) | Homogeneous |
p18 -/- | BALB/c | Â | p18 homozygous null | [8] | Erbb2-likeEx (5/9); Normal-likeEx (2/9); Squamous-likeEx (1/9) | Heterogeneous |
Pik3ca-H1047R | FVB | MMTV | Pik3ca H1047R mutation overexpression | [9] | Class14Ex (5/12); Squamous-likeEx (5/12); 2 others | Semi-homogeneous |
Rb -/- | Mixed | Â | Rb homozygous null | [10] | Erbb2-likeEx (4/10); NeuEx (1/10); 3 others | Heterogeneous |
Stat1 -/- | C57BL/6J | Â | Stat1 homozygous null | [11] | Stat1Ex (7/7) | Homogeneous |
TgMMTV-Aib1 | FVB | MMTV | Aib1 overexpression | [12] | Erbb2-likeEx (4/9); MycEx (2/9); 2 others | Heterogeneous |
TgMMTV-Atx | FVB | MMTV | Atx overexpression | [13] | Class14Ex (3/5); Squamous-likeEx (1/5); 1 other | Semi-homogeneous |
TgMMTV-Fgf3 | FVB | MMTV | Fgf3 overexpression | [14] | Erbb2-likeEx (2/5); Normal-likeEx (2/5); Wnt1-LateEx (1/5) | Semi-homogeneous |
TgMMTV-Hras | FVB | MMTV | Hras overexpression | [15] | NeuEx (5/8); Class8Ex (2/8) | Semi-homogeneous |
TgMMTV-Lpa | FVB | MMTV | Lpa1, Lpa2, or Lpa3 overexpression | [12] | Normal-likeEx (6/15); Claudin-lowEx (3/15); 3 others | Heterogeneous |
TgMMTV-Myc | FVB | MMTV | cMyc overexpression | [15] | MycEx (4/5); Class8Ex (1/5) | Homogeneous |
TgMMTV-Wnt1,iFgfr | FVB | MMTV | Wnt1 overexpression, inducible Fgfr1 or Fgfr2 | [16] | Wnt1-EarlyEx (7/12) | Homogeneous |
TgWAPCre-Etv6 | Mixed | WAP | Etv6-Ntrk3 fusion gene overexpression | [17] | Erbb2-likeEx (12/12) | Homogeneous |
Brca1+/-, Trp53+/-, irradiated | BALB/c | Â | Brca1 and Trp53 heterozygous, irradiated | [18] | p53null-BasalEx (6/7); Wnt1-EarlyEx (1/7) | Homogeneous |
DMBA-induced | FVB | Â | DMBA treated | [19] | Squamous-likeEx (4/11); Claudin-lowEx (3/11); 3 others | Heterogeneous |
Normal mammary | Mixed | Â | Normal mammary tissue | Â | Normal-likeEx (16/16) | Homogeneous |
TgC3(1)-Tag | FVB | C3(1) | SV40 large T antigen | [20] | C3TagEx (28/30); Claudin-lowEx (2/30) | Homogeneous |
TgMMTV-Cre Brca1Co/Co, Trp53+/- | C57BL/6J | MMTV | Brca1 flox, Trp53 heterozygous | [21] | p53null-BasalEx (4/10); Claudin-lowEx (3/10); 1 other | Heterogeneous |
TgMMTV-Neu | FVB | MMTV | Rat Her2 overexpression | [22] | NeuEx (25/28); Normal-likeEx (2/28); 1 other | Homogeneous |
TgMMTV-PyMT | FVB | MMTV | Py-MT overexpression | [23] | PyMTEx (9/17); Class3Ex (1/17) | Homogeneous |
TgMMTV-Wnt1 | FVB | MMTV | Wnt1 overexpression | [24] | Wnt1-EarlyEx (15/25); Wnt1-LateEx (7/25); 3 others | Semi-homogeneous |
TgWAP-Int3 | FVB | WAP | Notch4 overexpression | [25] | WapINT3Ex (6/7); Class3Ex (1/7) | Homogeneous |
TgWAP-Myc | FVB | WAP | cMyc overexpression | [26] | MycEx (18/21); Class8Ex (3/21) | Homogeneous |
TgWAP-T121 | Mixed | WAP | pRb, p107, p130 inactivation | [27] | Erbb2-likeEx (3/6); Class3Ex (2/6); Claudin-lowEx (1/6) | Semi-homogeneous |
TgWAP-T121, Trp53+/- | B6D2F1 | WAP | pRb, p107, p130 inactivation, Trp53het | [27] | C3TagEx (1/1) | Â |
TgWAP-Tag | C57BL/6J | WAP | SV40 large T antigen | [28] | C3TagEx (4/4) | Homogeneous |
Trp53 -/- | BALB/c | Â | Trp53 homozygous null | [29] | p53null-LuminalEx (27/58); p53null-BasalEx (15/58); 5 others | Heterogeneous |
Trp53+/-, irradiated | BALB/c | Â | Trp53 heterozygous, irradiated | [30] | p53null-BasalEx (4/8); Claudin-lowEx (2/8); 2 others | Heterogeneous |