Figure 4
From: Cell-cycle regulated transcription associates with DNA replication timing in yeast and human
Transcription and T rep in human. (A) No oscillation is observed when comparing the Trep versus expression levels of all cell cycle-regulated genes in HeLa cells (all |r| > 0.063 are significant at P < 0.05; the four time-points that exceed this are within the range expected by chance, given that 47 time-points were analyzed). (B) Significant oscillation is observed when comparing Trep versus expression levels of cell cycle-regulated genes with late Trep (red line; the final 50% of S phase; all |r| > 0.195 are significant), but not early Trep (blue line). (C) Significant oscillation is observed when comparing Trep versus expression levels of cell cycle-regulated genes within 10 kb of an ORI (blue line; all |r| > 0.197 are significant), but not further than 10 kb from an ORI (red line).