Figure 3

Distribution of the DRMs in the five different cell lines. (a) Densities of the regions in the whole genome, defined as the running fractions of bases covered by the regions. The tracks are, respectively, from the outermost to the innermost, the ideogram for the human karyotype (genome build hg19), Gencode version 7 level 1 and level 2 genes, and regions in GM12878, H1-hESC, HeLa-S3, Hep-G2 and K562. The five innermost tracks are all in the same scale. Box i shows an area with an exceptionally high density of DRMs on chromosome 19 in the h1-hESC line. Box ii shows an area with exceptionally high density of DRMs on chromosome 5 in HeLa-S3 cells. (b) Fraction of bins covered by the six types of regions shared by different numbers of cell lines. (c) Fraction of bins covered by the six types of regions shared by the 31 possible combinations of the 5 cell lines. Box i marks the high fraction of BIR bins shared by cell lines GM12878, H1-hESC, HeLa-S3, and K562.