Exome sequencing identifies a missense mutation in Isl1associated with low penetrance otitis media in dearisch mice

Table 4 Analysis of offspring from dearisch matings

	< 30	30 to 50	> 50	Total	Percent
Het × Het^a
WT	37 (23/15)	2 (1/1)	0 (0/0)	39	35.10%
Het	32 (25/7)	21 (13/8)	19 (13/6)	72	64.90%
Hom	0 (0/0)	0 (0/0)	0 (0/0)	0	0.00%
Total	69	23	19	111
Percent	62.20%	20.70%	17.10%
Het × WT ^b
WT	35 (19/16)	1 (1/0)	0 (0/0)	36	42.40%
Het	27 (15/12)	13 (8/5)	9 (6/3)	49	57.60%
Hom	0 (0/0)	0 (0/0)	0 (0/0)	0	0.00%
Total	62	14	9	85
Percent	72.90%	16.50%	10.60%

^aThe genotypes and ABR click thresholds of mice from the dearisch colony born to known heterozygote (Het) by heterozygote matings. ^bThe genotypes and click-evoked ABR thresholds of mice from the dearisch colony born to known heterozygote by wild type (WT) matings. The number of mice in each category is given, with number of males/number of females in parentheses. Hom, homozygote.

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