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Table 6 Concentration of NAD, NADH, NADP, and NADPH

From: Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidisand human cells

 

Control

0.16 μM IQ-143

1.25 μM IQ-143

 

Mean (μg/ml)

SD

Mean (μg/ml)

SD

% of control

Mean (μg/ml)

SD

% of control

NAD

42.19

2.44

35.68**

0.92

84.57

27.89**

0.95

66.11

NADH

3.71

0.31

2.63**

0.28

70.89

1.95**

0.21

52.56

NADP

3.47

0.06

3.24**

0.05

93.37

2.42**

0.05

69.74

NADPH

2.87

0.12

2.25**

0.02

78.40

5.56**

0.22

193.73

  1. Direct measurement of NAD, NADH, NADP, and NADPH concentrations in S. aureus (in μg/ml and percentage of control value depending on the applied IQ-143 concentration). Statistically significant differences are indicated (*P < 0.05,**P < 0.01). SD, standard deviation.
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Genome Biology

ISSN: 1474-760X

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