Figure 2From: Interrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in seraFunctional group essentiality. The percentage of genes in each functional group shown to be essential by TraSH during the initial library selection. The origin is set to 26%, the percentage of essential genes in the whole genome. Cell envelope genes include those involved in peptidoglycan, capsule and lipopolysaccaride (LPS) synthesis as well as pili; cell processes includes genes associated with cell division, pathology, and so on; intermediate metabolism includes phosphate and sulfur metabolism; energy metabolism includes glycolysis, the pentose phosphate pathway, the tricarboxylic acid cycle, fermentation, electron transport and ATP synthesis; mobile elements includes prophage-, plasmid- and transposon-associated genes; other categories are self-explanatory.Back to article page