Figure 1From: Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damageOocyte activation after ICSI with sperm from mice with NPYq deficiency. (a) Epididymal sperm from males with severe NPYq deficiency (9/10NPYq- and NPYq-2) but not from males with moderate NPYq gene loss (2/3NPYq-) were less able to activate oocytes than epididymal sperm from their appropriate controls, as revealed by Fisher's exact test (d, P < 0.0001 versus matching sperm type in control). Epididymal sperm from males with severe NPYq deficiency (9/10NPYq- and NPYq-2) but not from males with moderate NPYq gene loss (2/3NPYq-) were less able to activate oocytes than testicular sperm, as revealed by Mantel-Haenszel chi square analysis (**P < 0.01, ***P < 0.001). (b) Genotype/source interaction revealed by ANOVA, showing that NPYq deficiency preferentially impairs oocyte activation with epididymal sperm (P = 0.038). Two males were used per genotype; four sperm groups (epididymal, frozen epididymal, testicular and frozen testicular) were examined per male; approximately 25 (24.88 ± 8.03) oocytes were scored per sperm group per male.Back to article page