Table 1 Enrichment P-values for overrepresented regulatory path motifs. Enrichment P-values for overrepresented regulatory path motifs in deletion and overexpression data with the two randomization methods described in the Methods. The complete tables for all 39 paths can be found in Tables S4 and S5 in Additional File 1).
From: Characterizing regulatory path motifs in integrated networks using perturbational data
Regulatory path | Perturbational data randomization | Physical network randomization |
|---|---|---|
| Â | Deletion data | |
TRI | 7.3 × 10-38 | 4.08 × 10-34 |
TRI-TRI | 6.95 × 10-7 | 1.41 × 10-4 |
TRI-PPI | 5.66 × 10-3 | 1.77 × 10-2 |
PPI-TRI | 1.96 × 10-17 | 1.87 × 10-10 |
PPI-PhI-TRI | 8.10 × 10-3 | 1.4 × 10-3 |
PPI-TRI-TRI | 2.01 × 10-3 | 2.1 × 10-3 |
| Â | Overexpression data | |
TRI | 1.1 × 10-13 | 2.46 × 10-9 |
TRI-TRI | 2.74 × 10-7 | 2.02 × 10-2 |
PPI-TRI | 1.21 × 10-7 | 7.54 × 10-4 |
PPI-PhI-TRI | 2.59 × 10-5 | 8.20 × 10-4 |
PPI-TRI-TRI | 1.58 × 10-7 | 3.27 × 10-4 |
TRI-PhI-TRI | 6.17 × 10-8 | 6.32 × 10-2 |
TRI-PPI-TRI | 1.96 × 10-4 | 6.12 × 10-2 |