Table 1 Ten highest TIF genes in the colorectal cancer dataset
Gene | TIF | t-score (P-value) | KEGG annotation | GO annotation (evidence codea) |
|---|---|---|---|---|
SLC25A5 | 1.34 | 4.79 (2e-6) | Calcium signaling pathway Parkinson's disease Huntington's disease | Function: Adenine transmembrane transporter activity (TAS) Process: Transport (TAS) |
CCR7 | 1.33 | 1.90 (0.06) | Cytokine-cytokine receptor interaction | Function: G-protein coupled receptor activity (TAS) Process: Chemotaxis (TAS) Elevation of cytosolic calcium ion concentration (TAS) Inflammatory response (TAS) |
VDAC1 | 1.32 | 5.82 (6e-9) | Calcium signaling pathway Parkinson's disease Huntington's disease | Function: Protein binding (IPI) Voltage-gated anion channel activity (TAS) Process: Anion transport (TAS) |
TCF7L1 | 1.32 | 6.02 (2e-9) | Wnt signaling pathway Adherens junction Melanogenesis Pathways in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Acute myeloid leukemia | Function: Transcription factor activity (NAS) Process: Establishment or maintenance of chromatin architecture (NAS) Regulation of Wnt receptor signaling pathway (NAS) |
NCAM1 | 1.32 | 5.80 (7e-9) | Cell adhesion molecules (CAMs) | Process: Cell adhesion (NAS) |
SERPING1 | 1.32 | 7.60 (3e-14) | Complement and coagulation cascades | Process: Blood circulation (TAS) |
C1R | 1.32 | 4.70 (3e-6) | Complement and coagulation cascades Systemic lupus erythematosus | Function: Serine-type endopeptidase activity (TAS) |
PPID | 1.32 | 4.04 (5e-5) | Calcium signaling pathway Parkinson's disease Huntington's disease | Function: Cyclosporin A binding (TAS) Protein binding (IPI) |
HADH | 1.32 | 5.94 (3e-09) | Fatty acid elongation in mitochondria Fatty acid metabolism Valine, leucine and isoleucine degradation Geraniol degradation Lysine degradation Tryptophan metabolism Butanoate metabolism Caprolactam degradation | Function: 3-hydroxyacyl-CoA dehydrogenase activity (EXP, TAS) |
GOT1 | 1.30 | 3.69 (0.0002) | Glutamate metabolism Alanine and aspartate metabolism Cysteine metabolism Arginine and proline metabolism Tyrosine metabolism Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Alkaloid biosynthesis I | Function: L-aspartate:2-oxoglutarate aminotransferase activity (EXP, IDA) Process: Aspartate catabolic process (IDA) cellular response to insulin stimulus (IEP) response to glucocorticoid stimulus (IEP) |