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Table 1 Gene Ontology biological process categories enriched in the set of genes represented in modular subnetworks

From: Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegansaging

Gene Ontology biological process

P-value

Translation

6.45E-17

Hermaphrodite genitalia development

1.20E-16

Embryonic cleavage

1.37E-15

Germline cell cycle switching, mitotic to meiotic cell cycle

8.32E-14

Locomotory behavior

1.84E-13

Meiosis

1.10E-11

Positive regulation of multicellular organism growth

4.25E-11

Morphogenesis of an epithelium

3.85E-06

Protein catabolic process

1.13E-05

Phosphate transport

4.99E-04

Negative regulation of multicellular organism growth

8.07E-04

Ubiquitin-dependent protein catabolic process

1.94E-03

Nucleosome assembly

1.97E-03

Establishment of nucleus localization

2.37E-03

Tricarboxylic acid cycle

3.26E-03

DNA replication

4.64E-03

Protein transport

5.01E-03

Energy coupled proton transport, against electrochemical gradient

5.02E-03

Leucyl-tRNA aminoacylation

5.02E-03

Collagen and cuticulin-based cuticle development

5.12E-03

Organelle organization and biogenesis

5.19E-03

Chromosome segregation

7.48E-03

mRNA metabolic process

8.44E-03

Protein import into nucleus

1.15E-02

Purine base biosynthetic process

1.15E-02

Sulfur compound biosynthetic process

1.40E-02

DNA repair

1.45E-02

Determination of adult life span

1.74E-02

Threonine metabolic process

1.75E-02

Water-soluble vitamin biosynthetic process

1.78E-02

ATP synthesis coupled proton transport

3.14E-02

rRNA processing

3.85E-02

Isoleucyl-tRNA aminoacylation

4.02E-02

Methionyl-tRNA aminoacylation

4.02E-02

Valyl-tRNA aminoacylation

4.02E-02

Embryonic pattern specification

4.04E-02

Regulation of cell cycle

4.04E-02

  1. All categories shown are significant at P < 0.05 after an FDR correction for multiple testing. GO categories written in italics are also enriched for known longevity genes (Additional file 4).