Skip to main content

Table 4 Average endocannabinoid levels of FAAH and MGLL rare variant carrier groups at the most significant locus-variants in the three intervals

From: Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level

 

AEA

2-AG

 

N

Average (pmol/ml)

SD

P-valuea

N

Average (pmol/ml)

SD

P-valuea

FAAH promoter locus-variant

   

0.05

   

0.10

   Carrier

        

Cases

14

17.11

5.79

 

14

10.55

10.67

 

Controls

0

NA

NA

 

0

NA

NA

 

   Non-carrier

        

Cases

80

15.13

5.34

 

67

5.63

3.04

 

Controls

48

13.76

5.51

 

35

6.98

4.15

 

MGLL intron 3 locus-variant

   

0.49

   

0.80

   Carrier

        

Cases

5

15.6

6.35

 

4

6.43

2.08

 

Controls

0

NA

NA

 

0

NA

NA

 

   Non-carrier

        

Cases

89

15.24

5.44

 

77

6.49

5.57

 

Controls

48

13.76

5.52

 

35

6.99

4.16

 

MGLL promoter locus-variant

   

0.36

   

0.37

   Carrier

        

Cases

26

15.09

5.6

 

24

6.31

3.06

 

Controls

3

13.16

5.38

 

3

4.41

4.46

 

   Non-carrier

        

Cases

68

15.56

5.43

 

57

6.56

6.2

 

Controls

45

13.8

5.58

 

32

7.22

4.11

 
  1. aTwo-tailed t-test P-value between carriers/cases and non-carriers/controls. NA, not available.
Back to article page

Genome Biology

ISSN: 1474-760X

Contact us