Figure 4From: Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite levelAssociation with BMI. (a) Significance of the association with BMI identified by single marker tests (-log10(chi-square P-value)) for all SNVs located in the MGLL interval (x-axis, NCBI36 coordinates). SNPs with a P-value < 0.01 are highlighted in red. The recombination rate [56] in the HapMap CEU population for this region is indicated by a blue line and measured on the right axis. (b,c) Significance of the association with BMI for all locus-variants identified by RareCover (see Materials and methods) in the MGLL (a) and FAAH (b) sequenced intervals. For both genes, locus-variants with a P-value < 0.01 are highlighted in red. The MGLL and FAAH gene structures are aligned based on their genomic positions.Back to article page