Table 3 Comparisons between fish and human metabolic pathways
Most conserved pathways | ||||
|---|---|---|---|---|
Pathway | Human ECs | Fish ECs | Overlap | Ratio |
1- and 2-Methylnaphthalene degradation | 2 | 3 | 2 | 1 |
Hyaluronan metabolism | 3 | 3 | 3 | 1 |
Sialic acid metabolism | 18 | 18 | 18 | 1 |
Hexose phosphorylation | 5 | 5 | 5 | 1 |
Electron transport chain | 4 | 5 | 4 | 1 |
Limonene and pinene degradation | 3 | 4 | 3 | 1 |
Proteoglycan biosynthesis | 16 | 16 | 16 | 1 |
Glycosphingolipid biosynthesis - ganglioseries | 18 | 17 | 17 | 0.94 |
N-Glycan degradation | 8 | 7 | 7 | 0.87 |
Di-unsaturated fatty acid beta-oxidation | 7 | 6 | 6 | 0.85 |
Vitamin B1 (thiamin) metabolism | 7 | 6 | 6 | 0.85 |
Glycosphingolipid metabolism | 28 | 24 | 24 | 0.85 |
Glutamate metabolism | 14 | 12 | 12 | 0.85 |
TCA cycle | 18 | 15 | 15 | 0.83 |
Vitamin B9 (folate) metabolism | 17 | 14 | 14 | 0.82 |
Linoleate metabolism | 11 | 9 | 9 | 0.81 |
Least conserved pathways | ||||
Pathway | Human ECs | Fish ECs | Overlap | Ratio |
Phytanic acid peroxisomal oxidation | 13 | 5 | 5 | 0.38 |
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | 3 | 1 | 1 | 0.33 |
Vitamin H (biotin) metabolism | 6 | 2 | 2 | 0.33 |
Vitamin B12 (cyanocobalamin) metabolism | 3 | 2 | 1 | 0.33 |
Glyoxylate and Dicarboxylate metabolism | 7 | 2 | 2 | 0.28 |
Pentose and Glucuronate interconversions | 9 | 2 | 2 | 0.22 |
Ascorbate (vitamin C) and aldarate metabolism | 8 | 1 | 1 | 0.12 |