Figure 1From: Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noiseVariance in weights of mice haploinsufficient for Dnmt3a. (a) Mice from paternal and maternal transmission of the Dnmt3a- null allele and the Dmnt1MommeD2 allele were weighed and genotyped at 3 weeks of age (weaning). The data presented in these graphs are tabulated below. (b) There is significantly more variation in the weights of Dnmt3a-/+ mice following paternal transmission of the mutant allele (F test, P = 0.01). Dnmt3a- data were collected from wild-type and heterozygous mutant littermates from a wild-type x heterozygous cross. Dmnt1MommeD2 data were collected from wild-type x heterozygous crosses (equal contributions from reciprocal crosses) and heterozygous intercrosses.Back to article page