Genes encoding components involved in mtDNA metabolism | Â | Â |
   *YKL114c | APN1 | Involved in repair of DNA damage; located in nucleus and mitochondria |
   YLR304c | ACO1 | Aconitase; also independently required for mtDNA maintenance |
   YML061c | PIF1 | DNA helicase; active in nucleus and mitochondria |
   YOL095c | HMI1 | Mitochondrial inner membrane localized DNA helicase |
   YOR330c | MIP1 | Catalytic subunit of the mitochondrial DNA polymerase |
Genes encoding components involved in mitochondrial transcription and translation | Â | Â |
   *YBR268w | MRPL37 | Mitochondrial ribosomal protein |
   *YCR024c | SLM5 | Mitochondrial asparaginyl-tRNA synthetase |
   *YDR175c | RSM24 | Mitochondrial ribosomal protein of the small subunit |
   YHR168w | MTG2 | Associates with mitochondrial ribosome; possible role in ribosome assembly |
   *YKL169c |  | Dubious ORF; partially overlaps with MRPL38 |
   YMR228w | MTF1 | Mitochondrial RNA polymerase specificity factor |
Genes encoding components involved in oxidative phosphorylation | Â | Â |
   *YDR079w | PET100 | Specifically facilitates the assembly of cytochrome c oxidase |
   YPL078c | ATP4 | Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase |
Other genes | Â | Â |
   *YGL240w | DOC1 | Required for the ubiquitination activity of the anaphase promoting complex |
   *YLR091w | RRG5 | Unknown function |
   YOR211c | MGM1 | Mitochondrial GTPase involved in fusion |