Figure 2

Correlation of elongation inhibition with epigenetic peaks. (a, b) The average of nucleosome level (left panel) and methylation level (right panel) were plotted (a) within each expression percentile and (b) within each bin of elongation efficiency. The epigenetic marks near the start codon are scaled on the left side (black curve) and those near the stop codon on the right side (gray curve). (c-e) Density of Ser5-phosphorylated Pol II (black trace) and nucleosome level (gray) surrounding the start codon (left panel) or stop codon (right panel) for (c) all genes, (d) genes with a long (> 5 kb) 5' UTR (left panel) or 3' UTR (right panel), and (e) genes with high- or low-occupancy boundary nucleosomes (top 10% or bottom 10%). The Pol II scale is on the left side and the nucleosome scale is on the right side.