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Figure 8 | Genome Biology

Figure 8

From: Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels

Figure 8

Analysis of SNPs in candidate genes within the Obrq13 QTL region of mouse chromosome 17 that has a protective effect on liver triglyceride levels. Shown is an example of histology of the liver of a C57BL/6J male and a consomic mouse carrying the Obrq13 region from A/J, which has a protective effect on the accumulation of liver triglycerides when animals are placed on a high fat diet [16]. Using the sequence of A/J chromosome 17, we called SNPs against the reference C57BL/6J genome and positioned them in candidate genes within the Obrq13 region. Non-coding SNPs are shown as red circles, non-synonymous SNPs are shown in green, synonymous SNPs are shown in yellow while the truncating and essential splice site SNPs found in a transcript of Lmf1 are shown as an open circle and an orange circle, respectively. The orientation of each gene relative to the forward strain is shown above the gene name as an arrow and genes are grouped together based on size (a scale is shown above each group of genes). Genes are displayed with 5 kb of genomic sequence 5' and 3'.

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Genome Biology

ISSN: 1474-760X

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