Figure 1

The conceptual framework of Wormnet. Wormnet was generated from large-scale studies of C. elegans biology (boxes). Data for each gene were weighted according to their accuracy, which is diagrammed here as differently sized boxes. Wormnet can be used to make predictions about gene function, which can be rapidly tested in vivo. 'Associalogs' refers to physical or genetic interaction data from yeast, flies, and humans mapped to their nematode orthologs.