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Figure 5 | Genome Biology

Figure 5

From: Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia

Figure 5

The proposed model of APL pathogenesis induced by PML-RARα. PML-RARα may activate the dysregulation of several TFs in the disease regulatory pathway in APL through six mediator TFs (dashed blue arrow). This regulatory circuitry ultimately converges on the overexpression of Rxra. Red circle, overexpressed TFs; green circle, underexpressed TFs; green box, underexpressed genes; orange circle, TFs in the normal network that are predicted as targets of dysregulated TFs in APL; gray circle, other TFs in the normal network; purple circle, PML-RARα.

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Genome Biology

ISSN: 1474-760X

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