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Table 2 DER values for T2DM and false positive genes from GWAS

From: FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease

Locus or SNP

Gene

Associated in populations

DER

Correct?a

2q37.3

CAPN10

Finish. [55], Korean [56], Mexican. [55], Tunisian [57]

0.57

True positive

3p25

PPARG

Caucasian. [58], Finish. [59], German. [60], Indian Sikhs. [61], Japanese. [62], Mexican. [63]

0.53

False negative

3q27.2

IGF2BP2

Asian. [64], Caucasian. [33], Chinese [65], Danish. [66], French. [67], German. [60], Hispanic. [68], Indian Sikhs. [61], Japanese. [69], Norwegian. [70]

0.54

False negative

6p22.3

CDKAL1

Asian. [64], Ashkenazi Jewish. [71], Caucasian. [33], Chinese [65], German. [60], Hispanic. [68], Japanese. [69], Norwegian. [70]

0.55

True positive

8q24.11

SLC30A8

Asian. [64], African. [68], Caucasian. [33], Chinese [65], Hispanic. [68], Japanese. [69], Norwegian. [70]

0.42

False negative

9p21

CDKN2A

Asian. [64], Caucasian. [34], Chinese [65], Danish. [66], French [72], Japanese. [69]

0.59

True positive

9p21

CDKN2B

Asian. [64], Caucasian. [33], Chinese [65], Danish. [66], French [72], Japanese. [69], Norwegian. [70]

0.49

False negative

10q23

HHEX

Asian. [64], Caucasian. [33], Chinese [65], Danish. [66], German. [60], Japanese. [69], Norwegian. [70]

0.58

True positive

10q23

IDE

Caucasian. [73], Chinese [65], Danish. [66], Japanese. [74], Korean. [75]

0.61

True positive

10q24

KIF11

Caucasian, Chinese [65], Danish. [66], Japanese. [74]

0.54

False negative

10q25.3

TCF7L2

African. [76], Ashkenazi Jewish. [71], Asian. [64], Caucasian. [33], Chinese. [77], German. [60], Hispanic. [78], Indian Sikhs. [61], Japanese. [79], Spanish, UK white. [80]

0.64

True positive

11p15.1

KCNJ11

Arab. [81], Caucasian. [33], Czech [82], Japanese. [69]

0.39

False negative

11p15.5

KCNQ1

Singaporean. [35], European. [35], Japanese. [35]

0.6

True positive

16q12.2

FTO

Asian. [64], Caucasian. [34], Indian Sikhs. [61], German. [60], Japanese. [83], Norwegian. [70]

0.55

True positive

20q12

HNF4A

Amish. [84], Ashkenazim [85], Danish. [86], Finish. [87], Swedish. [87], Mexican. [88], Norwegian. [89], UK Caucasian. [90]

0.63

True positive

rs11078674

NLGN2

No

0.53

True negative

rs2866016

TSPAN5

No

0.53

True negative

rs12629276

RFTN1

No

0.54

True negative

rs8101509

ZNF649

No

0.4

True negative

rs945384

FAM69B

No

0.53

True negative

rs2050831

VPS13A

No

0.63

False positive

rs6670163

RYR2

No

0.55

False positive

rs859101

SLC44A3

No

0.5

True negative

rs11084127

ZNF615

No

0.46

True negative

rs7950175

KIRREL3

No

0.48

True negative

rs13064991

SLC6A20

No

0.45

True negative

rs6541240

TTC13

No

0.51

True negative

rs2278419

ZNF350

No

0.45

True negative

  1. aThe predicted result using DER ≥ 0.55. DER, differential expression ratio; GWAS, genome-wide association study; T2DM, type 2 diabetes mellitus.