Figure 6From: Comprehensive characterization of the cis-regulatory code responsible for the spatio-temporal expression of olSix3.2in the developing medaka forebrainSummary of the regulatory code that control the entire expression of olSix3.2. (a) Early expression of olSix3.2 in the forebrain and eye depends on enhancers in module D and a silencer activity (activities) in module A. (b) olSix3.2 expression in the lens placode requires multiple elements distributed along modules D to H. (c) During organogenesis, correct olSix3.2 expression requires the activity of different enhancer arranged in a 5'to 3' mode within module I. The activity of I is repressed by module G, which, in turn, is neutralized initially by module H and at later stages (d) by the combined activity of the E and H silencers. Module A is necessary at all stages analyzed to prevent reporter expansion to caudal central nervous system.Back to article page