Morphine effects on striatal transcriptome in mice

Table 2 Summary of morphine-induced changes in gene expression level in the four inbred strains

Treatment	Fold change over control	All of the four strains	129P3/J strain	C57BL/6J strain	DBA/2J strain	SWR/J strain
Acute upregulation	>1.2^a	181	179	106	313	255
	>1.5	38	33	39	81	42
Acute downregulation	>1.2	69	44	108	68	67
	>1.5	6	4	25	25	14
Chronic upregulation	>1.2	76	90	116	59	63
	>1.5	13	17	38	8	10
Chronic downregulation	>1.2	145	83	278	98	141
	>1.5	9	9	61	10	12

The mouse strains evaluated were 129P3/J, C57BL/6J, DBA/2J, and SWR/J. ^aAnalysis was performed for the group of transcripts significantly changed after morphine treatment. Relative expression levels for 661 probe sets were computed using MBEI perfect match/mismatch (PM/MM) data.

ISSN: 1474-760X