Figure 4

Overview of interactive resource workflow of GSMN-TB. The user chooses one of four analysis protocols (computation of maximal growth rate, flux variability analysis [FVA], reaction essentiality scan, or single gene essentiality prediction). Depending on the choice, an appropriate input form is presented. The server runs linear programming using the genome scale metabolic reaction network of Mycobacterium tuberculosis. Constraints defined by the user overwrite the default set of constraints specified in the model file. Numerical results are formatted as HTML and sent to the user's browser. GSMN-TB, genome-scale metabolic network of M. tuberculosis.