From: Broad network-based predictability of Saccharomyces cerevisiaegene loss-of-function phenotypes
Phenotypea | AUC | Seed genes with phenotype (n) | Seed genes in network (n) | Ref. |
---|---|---|---|---|
Caspofungin sensitive | 0.996 | 20 | 18 | [36] |
Increased resistance to calcofluor white | 0.982 | 10 | 10 | [33] |
Unipolar budding | 0.941 | 10 | 10 | [68] |
CPY secretion (3) | 0.937 | 46 | 44 | [34] |
Cell cycle arrest defective | 0.930 | 8 | 8 | [74] |
UVC sensitive (high) | 0.919 | 15 | 14 | [75] |
Sensitivity at 15 generations in galactose | 0.908 | 17 | 14 | [4] |
CANR mutator (high) | 0.904 | 18 | 18 | [76] |
Haploinsufficient in rich medium (YPD) | 0.898 | 184 | 184 | [77] |
Cellular chitin level increased (3) | 0.873 | 22 | 21 | [33] |
Bleomycin resistant (3) | 0.871 | 5 | 4 | [37] |
Morphology: branched (diploid) | 0.870 | 5 | 5 | [4] |
Sensitivity at 15 generations in 1.5 M sorbitol | 0.867 | 6 | 4 | [4] |
Caspofungin resistant | 0.866 | 8 | 8 | [36] |
Inviable (essential) | 0.845 | 1100 | 1027 | [4,30] |
Shortened telomeres (3) | 0.843 | 20 | 18 | [32] |
Sensitivity at 15 generations in minimal +his +leu +ura medium | 0.843 | 77 | 70 | [4] |
MMS sensitive (3) | 0.837 | 78 | 73 | [78] |
Cellular chitin level reduced (2) | 0.835 | 17 | 17 | [33] |
Petite | 0.833 | 179 | 166 | [79] |
Sensitivity at 5 generations in minimal +his +leu +ura medium | 0.827 | 62 | 51 | [4] |
Long telomeres (3) | 0.824 | 6 | 6 | [32] |
Decreased calcofluor white resistance | 0.814 | 65 | 63 | [77,80] |
Growth defect on a fermentable carbon source | 0.812 | 257 | 249 | [81] |
Transposon cDNA expression changed (high) | 0.810 | 27 | 26 | [82] |
Morphology: clumpy (3)(diploid) | 0.802 | 18 | 18 | [4] |
Gamma radiation sensitive (3) | 0.793 | 31 | 31 | [83] |
Cell cycle arrest defective and defective shmoo | 0.782 | 30 | 29 | [74] |
Sensitivity at 5 generations in galactose | 0.781 | 11 | 10 | [4] |
Small (haploid) | 0.778 | 215 | 192 | [84] |
Retrotransposition reduced | 0.772 | 99 | 89 | [82] |
K1 killer toxin sensitive (40%) | 0.770 | 72 | 72 | [80] |
Increased iron uptake | 0.757 | 76 | 70 | [35] |
Growth defect on a non-fermentable carbon source | 0.755 | 498 | 448 | [81] |
Gentamycin sensitive (high) | 0.754 | 11 | 11 | [85] |
Proteasome inhibitor sens (high) | 0.753 | 22 | 22 | [86] |
Reduced fitness in rich medium (YPD) | 0.748 | 891 | 872 | [77] |
Mycophenolic acid sensitive | 0.746 | 38 | 33 | [87] |
Axial budding | 0.745 | 4 | 4 | [68] |
Morphology: elongate (3) (diploid) | 0.739 | 77 | 73 | [4] |
Sporulation deficient | 0.738 | 261 | 244 | [88] |
Random budding (high) | 0.737 | 74 | 72 | [68] |
Large (haploid) | 0.728 | 227 | 205 | [84] |
Reduced sporulation (3) (normal respiration) | 0.722 | 136 | 119 | [89] |
Bleomycin sensitive (4) | 0.721 | 58 | 55 | [37] |
Sensitivity at 5 generations in synthetic complete - lys medium | 0.715 | 23 | 22 | [4] |
Decreased rapamycin resistance | 0.707 | 272 | 256 | [90] |
Whi | 0.706 | 19 | 19 | [79] |
Sensitivity at 5 generations in 1.5 M sorbitol | 0.704 | 13 | 11 | [4] |
Decreased wortmannin resistance | 0.703 | 89 | 85 | [90] |
Sensitivity at 20 generations in 1 M NaCl | 0.703 | 63 | 59 | [4] |
K1 killer toxin resistant (40%) | 0.698 | 19 | 18 | [80] |
Morphology: round (3) (diploid) | 0.696 | 105 | 99 | [4] |
Uge | 0.694 | 28 | 26 | [79] |
Sensitivity at 5 generations in synthetic complete - trp medium | 0.694 | 48 | 45 | [4] |
Sensitivity at 5 generations in 1 M NaCl | 0.693 | 60 | 56 | [4] |
Rapamycin resist (2) | 0.692 | 26 | 26 | [91] |
Reduced iron uptake | 0.688 | 5 | 5 | [35] |
Rate of growth loss of growth in 0.85 M NaCl | 0.682 | 212 | 189 | [92] |
Sensitivity at 5 generations in medium of pH 8 | 0.677 | 102 | 93 | [4] |
Sensitivity at 15 generations in medium of pH 8 | 0.676 | 128 | 115 | [4] |
Morphology: small (3)(diploid) | 0.672 | 79 | 69 | [4] |
Sensitivity at 15 generations in 10 uM nystatin | 0.672 | 28 | 27 | [4] |
Morphology: large (3)(diploid) | 0.669 | 88 | 80 | [4] |
Reduced glycogen storage (2) | 0.666 | 44 | 41 | [93] |
Sensitivity at 5 generations in 10 uM nystatin | 0.666 | 124 | 108 | [4] |
Increased rapamycin resistance | 0.662 | 114 | 100 | [90] |
Morphology: unusual shmoo (haploid) | 0.661 | 29 | 25 | [74] |
Morphology: polarized bud growth (haploid) | 0.657 | 5 | 5 | [74] |
Wortmannin resistant (5) | 0.656 | 25 | 23 | [94] |
Sensitivity at 5 generations in synthetic complete - thr medium | 0.647 | 31 | 29 | [5] |
Enhanced glycogen storage (2) | 0.645 | 61 | 55 | [93] |
Proteasome inhibitor resistant | 0.642 | 7 | 6 | [86] |
Reduced spores per ascus | 0.641 | 37 | 34 | [89] |
Rate of growth sensitivity in 0.85 M NaCl | 0.629 | 209 | 191 | [92] |
Morphology: football (3) (diploid) | 0.628 | 59 | 53 | [5] |
Germination deficient | 0.627 | 158 | 147 | [88] |
Sporulation promoting | 0.622 | 102 | 98 | [88] |
6AU sensitive (3) | 0.618 | 28 | 26 | [95] |
Increased wortmannin resistance | 0.617 | 80 | 75 | [90] |
Morphology: elongated (haploid) | 0.603 | 110 | 101 | [74] |
Rapamycin sensitive (4) | 0.597 | 20 | 20 | [91] |
Efficiency of growth sensitivity in 0.85 M NaCl | 0.597 | 65 | 58 | [92] |
Decreased rapamycin resistance | 0.597 | 8 | 7 | [90] |
Slow growth in YPD (16× below WT) | 0.585 | 23 | 22 | [4] |
MPA sensitive (3) | 0.563 | 24 | 22 | [95] |
Morphology: round (haploid) | 0.552 | 13 | 11 | [74] |
Efficiency of growth resistance in 0.85 M NaCl | 0.541 | 44 | 40 | [92] |
Sensitivity at 5 generations in synthetic complete medium | 0.531 | 88 | 78 | [5] |
Morphology: large (haploid) | 0.527 | 23 | 21 | [74] |
Adaptation time loss of growth in 0.85 M NaCl | 0.526 | 103 | 91 | [92] |
Adaptation time sensitivity in 0.85 M NaCl | 0.521 | 284 | 259 | [92] |
Decreased sensitivity to the anticancer drug, cisplatin | 0.512 | 22 | 19 | [96] |
Morphology: chain (diploid) | 0.485 | 5 | 5 | [5] |
Morphology: small (haploid) | 0.480 | 94 | 89 | [74] |
Rate of growth resistance in 0.85 M NaCl | 0.479 | 59 | 49 | [92] |
Morphology: clumped (haploid) | 0.479 | 32 | 28 | [74] |
Adaptation time resistance in 0.85 M NaCl | 0.465 | 69 | 60 | [92] |
Efficiency of growth loss of growth in 0.85 M NaCl | 0.464 | 23 | 21 | [92] |
Morphology: pointed (haploid) | 0.453 | 99 | 88 | [74] |