On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees

Table 1 Unfiltered dataset: comparison of evolutionary rates for genes in autosomes

	Genes in rearranged versus colinear chromosomes			Genes in rearranged chromosomes: within versus outside inversions
	Colinear	Rearranged	P value	Outside	Inside	P value
N	5,873	5,818		4,710	1,108
K_I	0.0128	0.0126	< 0.001	0.0128	0.0126	< 0.001
K_A	0.0033	0.003	< 0.001	0.0031	0.0028	0.048
K_S	0.0149	0.014	0.001	0.0146	0.0118	< 0.001
K_A/K_I	0.2535	0.2383	0.007	0.2393	0.2342	0.605

Evolutionary rates are compared for genes in colinear versus rearranged chromosomes between human and chimpanzee, and for genes in rearranged chromosomes but inside versus outside the major cytological evolutionary rearrangements between these two species. P values were calculated by means of permutation tests (1,000 random permutations).

ISSN: 1474-760X