Figure 4

GO trees for NAM9 and 14 significantly regulated genes at 80% posterior probability threshold (FDR 11%). The colors of the boxes indicate the significance of the various Gene Ontology (GO) terms. NAM9 encodes a mitochondrial ribosomal component of the small subunit, involved in translation and mitochondrial small ribosome subunit [39-41]. Yeast is unviable under NAM9 deletion [38]. NAM9 is a structural constituent of ribosome, and it can be seen that seven out of the 14 genes, together with NAM9, are involved in translation. Five of them are also a ribosomal structural constituent and encode mitochondrial ribosomal subunits. Among the 14 putatively regulated genes, all except one uncharacterized gene are associated with mitochondria. FDR, false discovery rate.