Figure 6

Visual representation of the human gene annotations of the 'Pleiades genes' project in PAZAR. (a) Cytoscape visualization. Human genes are represented as orange squares and transcription factors regulating them as circles (blue for human, purple for mouse and green for rat). The different species of transcription factors reflects the fact that assays on the regulation of human genes are often carried out in cell lines or with recombinant transcription factors from different organisms. The orange edges represent the annotated interactions between transcription factors and genes. The red edge visualizes an interaction between two transcription factors. The red box highlights the human transcription factor SPI1 (also called PU.1) and all the genes recorded as containing a transcription factor binding site for it. (b) PAZAR TF View detail for PU.1 annotations from the 'Pleiades genes' project. Only the first 6 binding sites (out of 60) are displayed, as well as the binding profile for the combined set dynamically generated by the MEME software [31].