Figure 6

The general metabolic response to glucose. (a) The matrix of pairwise correlations describing the similarity in the response of cells transferred to YPD at different stages of the process is shown. We also compared these responses with the response of vegetative cells and mature spores to YPD. Correlations were calculated on the basis of 936 genes whose expression is induced after the addition of glucose to vegetative cells (see Materials and methods and Additional data file 3). A similar correlation pattern was also observed on transfer to glucose solution (see Additional data file 2). (b-g) Expression patterns in log₂ ratios of specific gene groups: (b) rRNA processing genes [64] (see Additional data file 3); (c) gluconeogenesis module [64] (see Additional data file 3); (d) ribosomal proteins module [64] (see Additional data file 3); (e) 'process-specific' group (see Additional data file 3). (f,g) A group of genes that is (f) upregulated (see Additional data file 3) or (g) downregulated on transfer to YPD specifically after commitment (see Additional data file 3). See Materials and methods for the identification of groups shown in (e-g). Each expression profile is accompanied by a colored bar indicating the log₂ fold change.