Figure 2
From: Histone modifications: from genome-wide maps to functional insights
Effect of nucleosome distribution on chromatin immunoprecipitation. Uneven genomic distribution of nucleosomes (a) may cause a bias in the results of chromatin immunoprecipitation experiments (b). The bias may be solved by including ChIP controls for nucleosome density (see text) and subsequent normalization of the histone-modification ChIP data.