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Table 1 Fold change in gene expression after 4 h exposure to NCS as measured by microarrays and by quantitative real-time RT-PCR

From: Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis

Gene

Affy_ID

Fold induction microarray

Fold induction RT-PCR

  

C

LacZ

Rel-A (NFκB)

p53

ATM

C

Rel-A (NFκB)

p53

ATM

(a) Known direct targets of NFκB

TNFAIP3

202644_s_at

8.28

5.34

1.15

3.02

1.19

9.5

1.1

9.5

0.9

RELB

205205_at

3.7

2.89

0.82

2.95

0.91

15.7

6.0

21.3

2.5

TNFRSF9

207536_s_at

4.01

3.5

1.1

2.08

1.21

14.3

3.5

11.0

1.4

NFKBIA

201502_s_at

4.61

5.4

1.26

2.67

1.02

4.2

1.7

4.5

1.2

CD83

204440_at

3.46

2.99

1.0

1.73

1.06

6.5

1.0

5.7

1.3

IER3

201631_s_at

4.44

5.12

1.43

2.35

1.44

6.6

1.8

3.4

1.8

(b) Known direct targets of p53

ATF3

202672_s_at

3.44

3.74

7.03

1.54

1.47

5.2

5.9

1.6

1.6

EGR1

201694_s_at

2.78

1.77

6.77

1.04

1.02

4.4

13.4

0.7

2.4

JUN*

213281_at

2.01

1.45

2.71

1.36

1.25

6.6

3.9

0.64

2.5

FOS

209189_at

1.72

1.42

2.22

1.07

1.22

3.4

13.1

3.4

1.9

ETR101*

202081_at

1.97

2

2.6

1.06

1.13

2.0

3.0

1.4

1.4

GADD45A

203725_at

2.36

2.07

2.00

1.07

1.22

1.8

2.3

1.8

1.3

DUSP1

201041_s_at

2.06

2.57

3.45

1.11

1.22

2.2

4.5

2.0

1.9

  1. *These genes are not reported as direct targets of p53 but are known to be functionally related to p53.
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Genome Biology

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