From: The expression signature of in vitro senescence resembles mouse but not human aging
Gene Ontology category | Human senescence | Mouse senescence | ||||
---|---|---|---|---|---|---|
 | Aging mouse cerebellum | Aging mouse neocortex | Aging mouse heart | Aging mouse cerebellum | Aging mouse neocortex | Aging mouse heart |
ATP biosynthesis GO:0006754 | P = 0.00648 | - | P = 0.019 | P = 0.00262 | P = 0.0135 | P = 0.0222 |
Hydrogen-exporting ATPase activity GO:0008553 | P = 0.0284 | - | P = 0.00701 | P = 0.00293 | - | P = 0.00394 |
Pre-mRNA splicing factor activity GO:0008248 | - | - | P = 0.0229 | P = 0.00199 | P = 0.00533 | P = 0.000848 |
Hydrogen ion transporter activity GO:0015078 | P = 0.0134 | - | P = 0.00532 | P = 0.000814 | - | P = 0.023 |
Mitotic sister chromatid segregation GO:0000070 | - | - | - | P = 0.000947 | P = 0.0462 | P = 0.0103 |
Nuclear mRNA splicing via spliceosome GO:0000398 | - | - | P = 0.022 | P < 0.000001 | - | P = 0.000918 |
Spliceosome complex GO:0005681 | - | - | - | P = 0.000124 | P = 0.00589 | P = 0.0199 |
Lysosome GO:0005764 | - | - | P = 0.00545 | P = 0.00641 | - | P = 0.0449 |
Protein folding GO:0006457 | P = 0.0469 | - | - | P = 3.47e-06 | P = 1.25e-05 | - |
Regulation of cell cycle GO:0000074 | - | - | - | P = 1.74e-05 | P = 0.00372 | P = 0.0083 |
Metalloendopeptidase activity GO:0004222 | P = 0.0012 | P = 0.0115 | - | - | - | P = 0.00277 |
Nucleus GO:0005634 | - | - | - | P = 0.000188 | P = 0.00143 | P < 0.000001 |
Chaperonin-containing T-complex GO:0005832 | P = 0.0447 | - | - | P < 0.000001 | P < 0.000001 | - |
Negative regulation of cell proliferation GO:0008285 | - | - | P = 0.00615 | P = 0.00636 | - | P = 0.00246 |
Proton transport GO:0015992 | - | - | P = 0.0126 | P = 0.00713 | - | P = 0.0042 |
Endoplasmic reticulum GO:0005783 | - | P = 0.0402 | - | - | P = 0.0372 | P = 0.0272 |
Cytoskeleton GO:0005856 | - | - | - | P = 0.0347 | P = 0.0308 | P = 0.0251 |
RNA binding GO:0003723 | - | - | - | P = 0.00305 | P = 0.0112 | P = 4.89e-05 |
Cytoplasm GO:0005737 | - | - | - | P = 0.0137 | P = 0.00965 | P = 5.49e-05 |
Respiratory gaseous exchange GO:0007585 | - | - | - | P = 6.25e-05 | P = 8.77e-06 | P < 0.000001 |