Figure 2

Schematic representation of the membrane attachment of proteins with a myristoyl anchor (dark gray, space-filling atomic representation) in combination with different co-occurring membrane-attachment factors (coMAFs). Class I, plus palmitoyl anchor (also dark gray, space-filling); class II, plus cluster of positive charges (dark blue, spacefill); class III, plus PIP₂-specific binding domain (PIP₂ in space-filling, alkyl tails in cyan); class IV, plus transmembrane segments; class V, plus a domain for specific protein-membrane protein interactions. White space-filling molecules in the model membrane represent cholesterol and symbolize targeting to specialized compartments. Two different states of the calcium/myristoyl-switch of recoverin are depicted in the lower left of the figure (calcium ions in red). Visualization is with SwissPdb-Viewer [108].