Figure 4
From: The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases
Proposed reaction mechanism for HMGRP [7,18]. The side groups of the key catalytic residues, Lys267, Asp283, Glu83, and His381, are shown, and the substrate and products are shown with R representing the HMG portion. The reaction follows three stages (see text for details). A basically similar mechanism has been proposed for HMGRH [4].